Ruben Amorim has named an unchanged starting line-up from last week’s first-leg in Bilbao.
Skipper Bruno Fernandes again plays in an advanced role, alongside Alejandro Garnacho in support of Rasmus Hojlund.
Manchester United XI: Onana, Lindelof, Maguire, Yoro, Mazraoui, Casemiro, Ugarte, Dorgu, Garnacho, Fernandes, Hojlund.
Substitutes: Bayindir, Heaton, Amass, Fredricson, Kamason, Shaw, Eriksen, Mainoo, Mount, Amad, Mantato.
Athletic Bilbao are without Inaki and Nico Williams, plus top scorer Oihan Sancet as they look to overturn the hosts’ imposing advantage.
Athletic Bilbao XI: Agirrezabala, Gorosabel, Yeray, Unai Nunez, Yuri, Ruíz de Galarreta, Jauregizar, Djaló, Unai Gómez, Sannadi.
Substitutes: Unai Simon, Parades, Vesga, Guruzeta, Lekue, De Marcos, Prados, Peio Canales, Adama Boiro, Olabarrieta, Rego, Varela.
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